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Perhaps best known as the outspoken host of E!’s late night talk show, “Chelsea Lately,” Chelsea Handler continues to offer international audiences her fearless honesty and tongue-in-cheek commentary every weeknight. In support of her new book, Uganda Be Kidding Me, she sits down with Ronan Farrow to share some of her favorite stories and discuss her life and career.

In this clip, she reveals her serious side and tells Ronan Farrow there’s only so much Justin Bieber news she can care about.